EWSR1 has been identified as a translocation partner in a wide range of clinically and pathologically diverse tumours which include the Ewing family of tumours, desmoplastic small round cell tumour, myxoid liposarcomas, extra-skeletal myxoid chondrosarcoma, angiomatoid fibrous histiocytoma, CCS of soft tissue and clear cell sarcoma-like tumours of the gastrointestinal tract, primary pulmonary myxoid sarcoma, myoepithelial tumours of skin, soft tissue and bone and rare examples of low-grade fibro-myxoid sarcoma, sclerosing epithelioid fibrosarcoma and mesothelioma [25]. The gene discussed is EWSR1; the disease is histiocytoma, Angiomatoid fibrous.