The association between ADT and CV events was first demonstrated in 2006 when Keating et al [8] conducted a study of over 73,000 Medicare patients with localised prostate cancer which showed increase in the incidence of sudden cardiac death, coronary heart disease, myocardial infarction and diabetes among 36% of men on GnRH agonists. This evidence concerns the gene GNRH1 and diabetes mellitus.