NLRP3 and intervertebral disk degenerative disorder: In line with our result, a previous study showed that LINC00969 positively regulates the expression of the thioredoxin-interacting protein (TXNIP) and increases IDD degeneration by acting as a ceRNA for miR-335-3p and sponging it and modulating activation of NLRP3 inflammasome (39).