In stage II to IV non-acral melanoma, anxiety was negatively correlated with the IL-12 concentrations (P = 0.018, Rho = −0.421), depression positively with IFN-γ (P = 0.014, Rho = 0.425), and low QOL positively with IFN-γ (P = 0.008, Rho = 0.457), IL-10 (P = 0.027, Rho = 0.397), and IL-5 (P = 0.044, Rho = 0.363). The gene discussed is IFNG; the disease is major depressive disorder.