In non-acral melanoma, the anxiety was negatively correlated with the IL-4 (P = 0.042, Rho = −0.301) and IL-12 (P = 0.006, Rho = −0.382) concentrations, but there were no significant correlations between depression and QOL and any of the cytokines. This evidence concerns the gene IL4 and acral lentiginous melanoma.