TNF and depressive disorder: However, in patients with TNM stages II to IV, the anxiety was negatively correlated with the IL-4 (P = 0.030, Rho = −0.265), IL-12 (P = 0.025, Rho = −0.267), and TNF-α (P = 0.014, Rho = −0.287) concentrations, and the depression (P = 0.046, Rho = 0.231) and low QOL (P = 0.025, Rho = 0.260) were positively correlated with IFN-γ concentration.