However, in TNM stage 0 or I non-acral melanoma, depression was negatively correlated with IL-12 (P = 0.018, Rho = −0.534) concentrations, and low QOL negatively with IL-12 (P = 0.043, Rho = −0.468) and IL-2 (P = 0.023, Rho = −0.519). Here, IL2 is linked to major depressive disorder.