ICA1 and metabolic syndrome: Similarly, autoreactive T cells and antibodies specific to several cytosolic self-antigens including glutamate decarboxylase 1 (GAD1), islet cell autoantigen 1 (ICA1), INSM transcriptional repressor 1 (INSM1) and solute carrier family 30 member 8 (SLC30A8) have been reported in the serum of patients with metabolic syndrome and type 2 Diabetes (T2D) (41).