In rheumatoid arthritis, fibroblast-like synoviocytes prefer glycolysis, accompanied by a higher expression of glucose transporter 1 (GLUT1) and 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 (PFKFB3) (22, 23). Here, PFKFB3 is linked to rheumatoid arthritis.