In murine colitis, including DSS-induced and IL-10- deficiency colitis, metabolomics revealed a significant increase in lactate levels and reduction in the proteins involved in oxidative phosphorylation, which implies that the respiratory state of the colon would switch to anaerobic metabolism because of the inflammation-induced hypoxia (52). This evidence concerns the gene IL10 and hyperinsulinemic hypoglycemia, familial, 4.