For the stromal compartment upon PFKFB3 inhibition by PFK15, as shown in Figure 9, less collagen (Figures 9A, B), fewer α-SMA expressing cells (Figures 9C, D), and fewer vimentin positive cells (Figures 9E, F) were observed following PFK15 treatment in DSS-induced colitis. Here, PFKFB3 is linked to colitis.