ISG15 and neoplasm: Seven days post tumor rechallenge, mice in the quadruple therapy group exhibited several significantly downregulated genes, including Irf7, Irak, Stat1, Cd40, Isg15, Itga1, etc. However, 21 days post-rechallenge, the combination therapy group had downregulated genes such as C3ar1, Cd8a, Cklf, Ccr3, Casp8, Sell, etc. upregulated genes, such as Cxcr3, Ccl5, Isg15, Camp, Thbs1, Mavs, etc. as compared to the control.