Regarding Epstein-Barr Virus (EBV) control, patients 1A and 2B had persistent EBV viremia, while patient 3A presented at 2 years of age EBV and Human herpesvirus-6 (HHV-6) encephalitis with positive PCR for EBV and HHV6 in brain tissue with CD8 lymphocyte infiltrates in brain biopsy. Here, CD8A is linked to viral encephalitis.