Since the co-localization of BCR and TLRs is crucial for the induction of AID in autoreactive B cells as well as establishment of central B cell tolerance, patients carrying IRAK-4, MYD88, UNC-93B and TACI mutations have increased numbers of polyreactive B cells in addition to their immunodeficiency syndromes. The gene discussed is AICDA; the disease is immunodeficiency disease.