IL12RB1 and neoplasm: Further, IgG-mono-IL12 would exhibit a longer serum half-life and higher tumor accumulation by avoiding the depletion by IL12R-expressing immune cells during circulation compared with its counterpart with two IL12 molecules, as previously observed with mono-mIL12-Fc (19) and other immunocytokines (46) Accordingly, the format of IgG-mono-IL12 may be superior to its counterpart bearing two molecules of IL12 in terms of induction of potent antitumor immune responses and pharmacokinetics, which remains to be determined in further studies.