Antiphospholipid syndrome (APS) is systemic autoimmune disease characterized by combination of vascular thrombosis, obstetrical complications and persistent presence of circulating antiphospholipid antibodies (aPLs) such as anti-β2-glycoprotein I (aβ2GPI), anticardiolipin antibodies (aCL) and lupus anticoagulant (LAC) (1). This evidence concerns the gene ACLY and autoimmune polyendocrinopathy.