In this context and in the context of RA models, it has been shown that, in particular, IL-6, IL-27R-induced IFNγ-producing TFH1 and TFH17 cells contribute to the induction of low St6gal1 expression in GC B cells and corresponding PCs as well as low IgG Fc sialylation levels (12, 67). This evidence concerns the gene IL6 and rheumatoid arthritis.