found that the depletion of m6A writer METTL3 promoted sorafenib resistance in HCC by reducing METTL3-mediated FOXO3 mRNA stability, while the overexpression of FOXO3 induced m6A-dependent sorafenib sensitivity by suppressing autophagy in HCC (37). The gene discussed is FOXO3; the disease is hepatocellular carcinoma.