We showed that the αCEA TCE specifically binds to CEA-positive CRC cells (HT-29, COLO 205; murine MC38 cells expressing human CEA/MC38CEA), pancreatic cancer cells (BxPC-3), breast cancer cells (MCF7) and lung cancer cells (A549), but not CEA-negative cells including glioblastoma U87MG and MC38WT (Supplementary Figure 1D). Here, CEACAM5 is linked to pancreatic neoplasm.