Upon confirmation that CEA depletion by siRNA did not negatively impact oncolytic vaccinia virus replication (Supplementary Figure 5A), we treated mice bearing murine MC38 cells expressing human CEA/MC38CEA tumours with 3 doses of 10 μg of αCEA TCE with or without 3 doses of VV-CTRL at 1E7 pfu (Figure 2C). The gene discussed is CEACAM5; the disease is neoplasm.