We also observed a decrease in cytotoxicity genes (FCER1G, CTSW, GZMB, GNLY, KLRF1, SPON2, FGFBP2, and PRF1) and activation markers (CD69 and KLRB1) in NK cells from patients with AD (Figure 2E). This evidence concerns the gene KLRB1 and Alzheimer disease.