Among these factors in the ELNs signature, the ELNs group, neutrophils, CDKN2B-AS1, MIR663AHG, and ZNF705A were protective factors for GC patients’ OS, with HRs of <1, and Tregs, H19, HOTTIP, LINC00643, TMEM236, and hsa-miR-135a-5p were risk factors, with HRs of >1. Here, HOTTIP is linked to gastric cancer.