ITGA5 and cancer: Among the 14 tumors in which the methylation level of cancer and adjacent tissues could be obtained, the methylation level of PIGK was significantly increased in 10 tumors, the methylation level of ITGA5 was significantly increased in 8 tumors and significantly decreased in 2 tumors, and the methylation level of ITGB1 was significantly increased in 6 tumors and significantly decreased in 3 tumors (Figure 3A and Supplementary Table 4).