We examined the expression of ITGA5 and PIGK in 114 pairs of colorectal cancers versus normal tissues using immunohistochemistry and showed that ITGA5 was significantly low expressed (Figures 12A, B, P=0.0024) and PIGK was significantly high expressed in colorectal cancers (Supplementary Figure 10A, B, P=0.023), which was consistent with our analysis. The gene discussed is ITGA5; the disease is colorectal cancer.