ITGA5 and laryngeal squamous cell carcinoma: It has been reported that ITGA5 mutations are related to the occurrence and development of various tumors, and overexpression of ITGA5 is connected with poor prognosis in a variety of gastrointestinal tumors, while in laryngeal squamous cell carcinoma, high ITGA5 expression is an independent adverse prognostic factor (30, 31).