In particular, sLAG3 (higher in NSCLC compared to UM and RCC) could be considered a marker of Th1 activation and DCs maturation, while high levels of sCTLA4 are associated with worse prognosis in patients affected by HNSCC, NSCLC, RCC and in colorectal cancer (CRC) (13, 14, 26–29). Here, LAG3 is linked to colorectal carcinoma.