PPIG and diabetes mellitus: At sacrifice, we found that in saline-treated group (control of CYP), diabetes did not alter the bladder weight (Figure 1D), edema score of the bladder (Figure 1E) or the vesical vascular permeability in bladder (Figure 1F), while in CYP-treated group, diabetes significantly increased bladder weight (Figure 1D), edema score of the bladder (Figure 1E) or the vesical vascular permeability in bladder (Figure 1F).