Furthermore, the frequency of immune cells (CD45+ cells) in the tumor microenvironment was increased in IL-6-/- animals with a higher rate of intratumoral dendritic cells (DCs) compared to WT mice (Figures 3B, C), but no significant differences were observed in the frequencies of intratumoral CD8+ and CD4+ T lymphocytes, and Treg (Figures 3D-F). Here, CD4 is linked to neoplasm.