PTEN and neoplasm: The miRNAs (miR-25-3p, miR-130b-3p, miR-425-5p) transferred from colorectal cancer (CRC) to macrophages via EVs can enhance M2 polarization by adjusting PTEN through the activation of PI3K/Akt signaling pathway, which finally leads to tumor EMT, angiogenesis, and liver metastasis (64).