EVs from metastatic osteosarcoma (K7M3 and DLM8) reduce the phagocytic function of alveolar macrophages via promoting TGF-β2 secretion, while there is no significant change in phagocytosis of macrophages taking up non-metastatic osteosarcoma (K7 and Dunn) -derived EVs (126). Here, TGFB2 is linked to osteosarcoma.