Gp130 (IL-6 receptor) is carried by TDEVs and interacts with macrophages to induce the phosphorylation and translocation of STAT3 to the nucleus, leading to an elevated expression of IL-6 and a shape of the pro-tumor cancer environment in several human breast cancer cell lines (MDA-MB231, MDA-MB-468, Hs578T, and MCF7) (118). The gene discussed is IL6; the disease is breast carcinoma.