TLR4 and familial pancreatic carcinoma: MiR-212-3p carried by pancreatic cancer cell-derived EVs inhibited the expression of regulatory factor X-associated protein (RFXAP) to decrease MHC II on DCs and induce immune tolerance (143), while miR-203 induced the downregulation of TLR4 and cytokines in DCs such as TNF-α and IL-12 in pancreatic cancer (113).