P2RY12 and Sepsis: The percent of platelet-CD4 lymphocytes aggregate was increased during sepsis as compared with the sham control group in male and female mice (Figure 3CP<0.05, male CLP vs male Sham and female CLP vs female sham), but in P2Y12 KO male mice platelets-CD4+ T cells aggregates were diminished, suggesting decreased platelets and CD4+ T cells interactions (Figure 3CP<0.05, male CLP vs male P2Y12 KO CLP).