To determine whether sepsis-induced platelet activation was sex-dependent or required P2Y12 or P2Y1 signaling, we measured p-selectin platelet surface expression in septic mice (WT, P2Y12 KO CLP and P2Y1 KO CLP) for both male (Figure 3A) and female (Figure 3B). Here, P2RY12 is linked to Sepsis.