Recently, it has been reported that B cells can release γ-aminobutyric acid (GABA), a well-known neurotransmitter molecule, which could promote the differentiation of monocytes into anti-inflammatory macrophages, thus secreting interleukin-10 (IL-10), and thereby inhibiting the anti-tumor CD8 T-cell response. The gene discussed is IL10; the disease is neoplasm.