Furthermore, NHP models have demonstrated that CD4+ T cell depletion alone is not the sole mechanism responsible for the greater risk of active TB during HIV coinfection, since antibody mediated T cell depletion is not sufficient to drive LTBI to active TB, and not all NHPs with HIV-mediated T cell depletion develop active TB (21–23, 25, 26, 30). The gene discussed is CD4; the disease is tuberculosis.