CD4 and infection: In contrast to this, in an LTBI NHP model comparing CD4+ T cell depletion to coinfection with SIV, Bucsan et al., 2019 (26) observed higher CCR5 T cells in the lungs of coinfected LTBI-SIV reactivator NHPs than just CD4 depleted-TB infected animals indicating higher recruitment to the primary site of infection in coinfected animals (26).