Indeed, Guo et al., 2017 (32) showed in a Chinese rhesus macaque NHP model, that pre-existing SIV infection led to an increase in extrapulmonary TB, higher bacterial counts in lungs, lymph nodes and extrapulmonary organs, and lower levels of IFNγ and IL-22 (cytokines known to inhibit Mtb infection) compared to Mtb infection alone (32). The gene discussed is IFNG; the disease is tuberculosis.