• 5 macrophage populations: resting, activated, Mtb-infected, HIV-infected, coinfected• 6 T cell populations: resting CD4+, Th1, HIV-1 infected CD4+, resting CD8+, HIV-1 specific cytotoxic, and Mtb specific cytotoxic• Intra- and extracellular Mtb• 5 cytokines: TNFα, IFNγ, IL-10, IL-12, IL-4• One compartment – lung• Fix TB related parameters to result in LTBI while varying HIV related parameters• Lymph node dynamics captured as first step. The gene discussed is TNF; the disease is tuberculosis.