• Simultaneous treatment with TB and HIV drugs reduces performance of HIV drugs• Best treatment of TB in coinfection is simultaneous TB and HIV drugs• Best treatment of HIV in coinfection is just HIV drugs without TB drugs• Improving performance of RTIs in CD4+ T cells shows decrease in infected CD4+ T cells but increase in HIV-infected macrophages• As HIV drug performs better in CD4+ T cells, HIV might selectively multiply in macrophages. This evidence concerns the gene CD4 and coinfection.