Therefore, the design of connecting the H-2KD binding insulin B chain peptide insulin B chain, amino acid 15-23 (IbsB15-23) to the N-terminal of β2m/CD3-ζ, made the mRNA encoding chimeric MHC-I receptor could target effector CD8 to diabetic CD8+ T cells, which reduced pancreatitis in NOD mice (153). This evidence concerns the gene INS and pancreatitis.