made a T1D vaccines using live attenuated Salmonella MvP728 (DhtrA/DpurD), cytokines (IL10 and TGF-β) and proinsulin (PPI) antigen combined with a subtherapeutic dose of anti-CD3 monoclonal antibody. The gene discussed is TGFB1; the disease is type 1 diabetes mellitus.