The most important dysregulated pathways by genes in greenyellow DE_Smodule are Interferons response pathways by the function of USP18, RSAD2, UBE2L6, GBP4, DDX58, GBP5, OASL, GBP1, GBP3, OAS2, OAS3, XAF1, TRIM6, IFI27, TRIM14, IFI6, IFIT2, EIF2AK2, IFIT1, IFIT3, TRIM5, STAT1, STAT2, HERC5, and MX1. Interferons are one the main defense mechanism against most viral infections such as hepatitis C, herpes simplex virus, measles as well as respiratory viruses including influenza and coronaviruses (41–43). Here, TRIM5 is linked to viral infectious disease.