The most important dysregulated pathways by genes in greenyellow DE_Smodule are Interferons response pathways by the function of USP18, RSAD2, UBE2L6, GBP4, DDX58, GBP5, OASL, GBP1, GBP3, OAS2, OAS3, XAF1, TRIM6, IFI27, TRIM14, IFI6, IFIT2, EIF2AK2, IFIT1, IFIT3, TRIM5, STAT1, STAT2, HERC5, and MX1. Interferons are one the main defense mechanism against most viral infections such as hepatitis C, herpes simplex virus, measles as well as respiratory viruses including influenza and coronaviruses (41–43). This evidence concerns the gene HERC5 and hepatitis A virus infection.