On the contrary, the SMO levels were downregulated in tumors relative to normal tissues in breast invasive carcinoma (BRCA), cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), kidney chromophobe (KICH), kidney renal clear cell carcinoma (KIRC), PCPG, thyroid carcinoma (THCA), and UCEC (Figure 4B). The gene discussed is SMO; the disease is invasive breast carcinoma.