Inflammasome NLRP3 expression is upregulated in DMD skeletal muscle fibers, where it is downregulated by ApN and its anti-inflammatory mediator Mir-711 and attenuates the dystrophic phenotype, suggesting that NLRP3 inhibitors may have therapeutic potential for muscle inflammation and myopathy (111). This evidence concerns the gene NLRP3 and Duchenne muscular dystrophy.