EIF2AK2 and periodontal disorder: In periodontal disease, double-stranded RNA (dsRNA)-dependent protein kinase R (PKR) regulates inflammation by regulating NLRP3 inflammasome surface through the NF-κB pathway (56) and migration inhibitor (57), microtubule affinity-regulating kinase 4 (58) and heat shock protein 90 (59, 60).