Tryptases can induce the production and release of multiple pro-inflammatory cytokines that directly cause and amplify psoriasis-associated inflammatory processes, such as IL-1β, IL-8, TNFα, and IL-6 production (20), and activate matrix metalloproteinases (MMP) to destroy various matrix components associated with the development of psoriatic arthritis (21). The gene discussed is CXCL8; the disease is psoriasis.