Pulmonary hypertension ↑ (90, 91)eNOS activity ↑ (92–94)NO production ↑ (92–94)Vasodilatation ↑ (92–94)Contractility ↓ (92–94)vascular permeability ↑ (95, 96)atherosclerosis susceptibility ↓ (97). This evidence concerns the gene NOS3 and pulmonary arterial hypertension.