Among them, the infiltration of tumor-killing cells such as activated B cell, mast cell, immature B cell, macrophage, myeloid-derived suppressor cells (MDSCs), effector memory CD8+ T cell and neutrophils in tumor tissues were significantly lower than that in normal tissues (Figure 7E), which suggest that the patterns of TME immune cell infiltration may contribute to immune escape and resistance to immunotherapy. The gene discussed is CD8A; the disease is neoplasm.