NFKB1 and glomerular disorder: In comparison, bulk RNA sequencing and microarray expression profiles of the glomerular compartment of kidney biopsies revealed a PMN-specific signature significantly enriched in NF-kB1 targets compared to other glomerulopathies, which is consistent with a GWAS finding of a variant at the NF-kB1 locus conferring an increased risk of PMN (75, 118).