In pemphigus vulgaris, an antibody-mediated autoimmune blistering skin disease, CAAR T cells expressing the disease autoantigen desmoglein 3 was able to eliminate desmoglein 3-specific B cells in a mouse model even in the presence of circulating autoantibodies and without off-target toxicity (168). This evidence concerns the gene DSG3 and pemphigus vulgaris.