INS and diabetes mellitus: Moreover, several studies have shown that statin therapy increases the incidence of DM (33–35), with the underlying mechanisms involving the following: calcium channels of pancreatic β cells that are related to insulin secretion; reduced potential of glucose transporter 4, which can lead to hyperglycemia and hyperinsulinemia; or altered intracellular signaling pathways owing to the reduction in major downstream signaling molecules, such as coenzyme Q10 (36).