A total of 20 genes were screened for dimensional reduction to construct the diagnostic model, and 10 genes were ultimately identified to the SARDS using the LASSO algorithm, including GBP1, LEF1, IFIT3, LRRN3, IFI44, LHFPL2, RTP4, CD27, EPHX2, and CXCL10. GBP1, as an IFN-γ-related gene in whole blood gene expression, was independently and positively correlated with T-bet+ frequency in Th17 cells, as the expression of T-bet in Th17.0 cells might indicate the degree of granulomatous inflammation in sarcoidosis patients (29). The gene discussed is LHFPL2; the disease is sarcoidosis.