The gene expression study confirmed the histological observation of increased fibrogenesis in COVID-19 patients, as genes related with collagen biosynthesis and ECM biosynthesis and degradation, such as COL1A2, COL3A1, COL6A3, COL1A1, COL5A1, SPP1, MMP14, NCSTN, and LOX were overexpressed in COVID-19 patients. Here, SPP1 is linked to COVID-19.