INS and Macrocephaly: We found earlier gestational age (Z = −3.427, P = 0.001), lower neonatal weight (Z = −2.200, P = 0.028), lower incidence of macrocephaly (χ2 = 4.092, P = 0.043) and lower incidence of maternal referral to ICU treatment (P = 0.014) in the insulin treatment group than in the control group (Table 3).