Another study analysed the whole blood samples of 180 idiopathic infertile males and 120 fertile controls to investigate the association between the occurrence of gene polymorphism (-656T>G and 1349>G variants in the ApE1 promoter and coding region) and the susceptibility to idiopathic male infertility (Yousefiet al. 2015). The gene discussed is APEX1; the disease is male infertility.