There was a significant difference in genotype distributions of -656T>G ApE1 polymorphism between infertile patients and controls. Findings indicated that individuals with the variant TG genotypes had a significant increased risk of idiopathic male infertility, whereas the significant association between the 1349T>G polymorphism and idiopathic male infertility risk was not observed.Therefore, the -656T>G ApE1 polymorphism may be associated with increased risk of idiopathic male infertility. The gene discussed is APEX1; the disease is male infertility.