Circulating levels of THBS2 was confirmed to be a potential diagnostic candidate in pancreatic cancer and lung cancer [15–17, 19], while the histological expression of THBS2 has been identified to be an independent prognostic biomarker for distal cholangiocarcinoma, colorectal cancer, and urothelial carcinoma [18, 22, 30]. This evidence concerns the gene THBS2 and colorectal cancer.