This is the first time that combined avatrombopag with other thrombopoietic agents has cooperative effect in vivo in the treatment of thrombocytopenia, which was consistent with the in vitro results that AKR-501 (avatrombopag) in combination with TPO had an additive effect on megakaryocytopoiesis [34]. This evidence concerns the gene TPO and Thrombocytopenia.