Additional adverse mechanisms include decreased uric acid excretion (potentially resulting in hyperuricaemia)(71,72), increased renal excretion of calcium and magnesium(73), higher insulin-like growth factor (IGF) levels(74) and decreased circulating adiponectin levels through acidosis-induced inhibition of adiponectin gene transcription in adipocytes(74,75). The gene discussed is ADIPOQ; the disease is hyperuricemia.