AKT1 and cancer: Other groups have demonstrated that tris DBA compounds decrease MAPK, PKC, and AKT-driven cancers as a result of NMT-1 blockade, however Musi et al. (2019) did not observe suppression of these pathways nor FAK inhibition and, interestingly, saw an increase in ERK and AKT phospho-activation despite increased UM apoptosis.