GNAQ and uveal melanoma: GNAQ p.Q209 mutations have been implicated in more than 90% of cases of GNAQ-driven uveal melanoma (UM), although, studies conflict regarding the downstream molecular interactions driving cancer formation and progression (Van Raamsdonk et al., 2009; Feng et al., 2019; Musi et al., 2019; Truong et al., 2020).