Similarly, in a 6-hydroxidopamine (6-OH)-induced PD rat model, PHB expression is upregulated in SN, and more in particular, in dying dopaminergic neurons, where PHB interacts with the mitochondrial complex I NADH-ubiquinone oxidoreductase 30 kDa subunit (NDUFS3), suggesting a possible role of PHB in neuroprotection of dopaminergic cells against mitochondrial dysfunction (Park et al., 2010). This evidence concerns the gene NDUFS3 and Parkinson disease.