For example, in a liquid chromatography tandem mass spectrometry study of ALS and FTD patients, Iridoy and colleagues observed that both PHB1 and PHB2 where downregulated, and Western blot (WB) analysis further confirmed a reduction of ≈15%–20% and ≈40%, respectively, in the spinal cord (Iridoy et al., 2018). This evidence concerns the gene PHB1 and frontotemporal dementia.