Among them, SCA14, which is a type of spinocerebellar ataxia (a group of cerebellar diseases characterized by progressive ataxia and cerebellar atrophy), is caused by missense mutations in PRKCG. PKCγ dysregulation leads to the abnormal dendritic development of Purkinje cells, which induces the onset of SCA14.25 Here, PRKCG is linked to Cerebellar atrophy.