Thus, the target of this research is to examine variations in adipocytokines [SFRP5, leptin, LGR4 and irisin] after 12 weeks of 4 types exercise training [high intensity interval training, resistance training, aerobic training and aerobic + resistance training] and as well as effects exercise Training Induced Calories Expenditure on Type 2 Diabetes Related Cardio Metabolic Physiological Parameters and adipocytokines in T2D patients. The gene discussed is LGR4; the disease is type 2 diabetes mellitus.