AGT and diabetic kidney disease: Diabetic Nephropathy is due to hemodynamic and structural changes including glomerular hyper filtration and hypertrophy, thickening of glomerular basement membrane, mesangial membrane expansion, tubulointestitial fibrosis, glomerular hypertrophy, podocyte and renal cell death, creatinine and protein excretion, renal dysfunction, irregular glomerular filtration rate, action of Angiotensin II by the over expression of AT1R receptors and imbalance in sex steroid hormone levels [26].