We treated him with local radiation therapy to the left eye and systemic osimertinib (EGFR-TKI).<h4>Conclusion</h4>To our knowledge, our case is the first report of a patient who initially presented with acute vision loss and was found to have metastatic retrobulbar optic nerve infiltration in one eye and metastatic choroidal lesion with exudative retinal detachment in the fellow eye secondary to lung adenocarcinoma. Here, EGFR is linked to lung adenocarcinoma.