A Kaplan-Meier curve28 was used to analyze the overall survival of the hub genes, among which CEP55, NMU, CAV1, TBX3, FBLN1 and SYNM had a P < 0.05, indicating that the expression of the seven hub genes selected from the NSCLC tissue samples has a certain significance on the prognosis and survival of the patients. The gene discussed is SYNM; the disease is non-small cell lung carcinoma.