Surprisingly, treatment with the GCGRi–insulin molecule resulted in an improved effect of treatment with exogenous glucagon as well as an improved effect of the spontaneous counter-regulatory response to hypoglycaemia, probably because the GCGRi inhibited glycogenolysis in the liver, so a larger amount of glycogen was available for glycogenolysis during hypoglycaemia. Here, INS is linked to Hypoglycemia.