MAP2K7 and non-small cell lung carcinoma: Interestingly, high expression of integrin/MEK/ERK target p21 has also been implicated in mediating cisplatin resistance in NSCLC and other cancers [108, 109] suggesting that elevated integrin signaling as a result of an ECM-High matreotype could underpin the chemotherapy resistance predicted for these tumors (Fig. 5B).