While several fibroblast subtypes (subtypes 2 (COX4I2-high), 4 (PLA2GA-high) and 5 (MMP3-high) as identified in [46]) were not detected in more than 10% of samples in this cohort, normal fibroblasts were significantly depleted in both tumor matreotypes compared with the non-tumor matreotype (Fig. 4D). Here, COX4I2 is linked to neoplasm.