Lung fibroblasts within these different compartments also display distinct phenotypes, and fibroblasts derived from SqCC tumors accumulate more than adenocarcinoma-associated fibroblasts via beta-1 integrin-dependent mechanisms [114], which may also accelerate matrisome-mediated pro-fibrogenic signaling in the ECM-High matreotype. The gene discussed is ITGB1; the disease is adenocarcinoma.