Chapman et al. detected 7 autoantibodies [p53, C-Myc, and hEGF, HER2, NY-ESO-1, CAGE, Mucin 1 (MUC1), and GBU4-5 antibodies] in 154 patients (104 LC patients and 50 normal), which had a diagnose sensitivity of 61% and specificity of 90%, respectively [35]. This evidence concerns the gene MUC1 and laryngotracheoesophageal cleft.